[wp-hackers] Running several WordPress sites on the same server

[Ryan WP Mailing Lists]

I am looking to run several WordPress sites on a server. I'm talking like
100+. The way I see it each wordpress site is the same except for
wp-content directory, wp-config.php and the database. Therefore my thought
is to have one install where wp-config.pho can use a central database to
dynamically designate the correct db as well as a unique wp-content
directory based on the domain name.

How would this compare to more of a shared hosting type setup with vhosts
and a full copy of the wp source for each site. Any downside to my method
or other considerations I should be aware of?